PDGF와 IGF-I이 배양된 사람 치은 및 치주인대 섬유모세포의 알카리성인산효소 활성에 미치는 영향
The Effect of PDGF and IGF-I on the Alkaline Phosphatase Activity of the Cultured Human Gingival and Periodontal Ligament Fibroblasts
구현웅, 신제원,
소속 상세정보
구현웅 ( ) - 경북대학교 치과대학 교정학교실
신제원 ( ) - 경북대학교 치과대학 교정학교실
KMID : 0355819990230010117
Abstract
-Abstract-
This study was designed to elucidate the factors inducing alkaline phosphatase
expression in healthy gingival and periodontal ligament fibroblasts. The cells incubated
with/without serum or growth factors (PDGF and IGF-I) were analysed by MTT assay
and ALP activity assay.
The results are as follows:
1. The withdrawal of serum from human gingival and PDL fibroblasts caused a
decrease in the cell proliferation and increase in the ALP expression.
2. ALP expression induced by serum withdrawal is inversely correlated with cellular
activity.
3. ALP expression induced by serum withdrawal is decreased by the application of low
concentrations of PDGF and IGF-I.
4. IGF-I enhances the ALP activity of human gingival and periodontal ligament
fibroblasts apparently.
키워드
원문 및 링크아웃 정보
등재저널 정보